New figures reveal cases of hospital-acquired infections are down at Calderdale and Huddersfield NHS Foundation Trust.
Reports of potentially killer superbug MRSA dropped from nine between January and March 2007 to five for the same period this year.
And cases of clostridium difficile in over 64s went down from 59 to 41.
Calderdale's hospital trust has been criticised in the past for missing superbug targets.
In March its chiefs were among seven across the country called to London by health watchdog Monitor and asked to explain why they had not met targets for cutting cases of infection.
The trust has been carrying out new measures to combat superbugs including trialling pioneering cleaning technology and introducing new floor signs and traffic light-style gel dispensers. Nationally experts from the Health Protection Agency said there was a 30 per cent fall in MRSA in 2007-2008.
The trust's director of nursing, Helen Thomson, said: "The figures are a reflection of the hard work of the hospital staff. Preventing healthcare associated infections is very much a priority for us.
"There are many ongoing initiatives specifically targeting infection prevention and control. The figures are also due to the support the trust receives from our visitors and patients and we thank them for it and ask them to continue helping us."