Traffic is backing up onto the Calderdale Way after lengthy delays on the M62 following a multi-car collision.
Four people are believed to have been injured on the M62, but the two taken to hospital are said to have suffered only minor injuries.
Fire crews from three stations attended the scene, as did the air ambulance.
The incident has caused congestion and there are currently delays of 30 minutes.
Normal traffic conditions are expected from 4.45 pm.