The Forget-Me-Not Children’s Hospice is opening a shop in Valley Road, Hebden Bridge, next month.
It will be the charity’s 10th shop and it has others in Halifax and Brighouse.
Around £2.5 million will have to be raised annually by the charity now it has opened its Huddersfield hospice to cater for West Yorkshire families.
In addition to selling donated items, the shops act as an information point to promote events.
There are more than 400 children and families in Kirklees, Calderdale and Wakefield who need the help the hospice offers.
Hannah Cockroft, of Mount Tabor, Halifax, a wheelchair sprinter and 2012 Paralympian hopeful, is the latest ambassador to declare her support for the hospice.
It has also recently benefited from a partnership with Mamas & Papas, which furnished the hospice and pledged to help with fund-raising.